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Anilkumar Gopalakrishnapillai

Research Scientist

¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ· Children's Hospital, Delaware 1600 Rockland Road Wilmington, DE 19803

Biography

Dr. Gopalakrishnapillai is currently serving as head of Cancer Stem Cell Laboratory at ¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ· Children's Hospital. He completed his Ph.D at Indian Institute of Science, Bangalore, India, postdoctoral research at University of California, Los Angeles and served as Associate Professor leading a lab in India, before joining ¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ· in 2012. His Current research is centered around developing novel targeted therapies for Down syndrome Myeloid Leukemia (DS-ML). He uses several strategies for developing disease models for DS-ML to understand disease biogenesis. Also actively engaged in characterizing the DS-ML stem cell population with a goal of specifically eradicating this population as a strategy to control disease relapse.

Education

  • Ph.D - Indian Institute of Science
  • Post Graduate Researcher - University of California

  • Leukemia, Hematological Malignancies Preclinical Model, Ipsc Disease Models, Cr

  • Down syndrome and leukemia: An insight into the disease biology and current treatment options.; Blood reviews; (2023).

  • Tetraspanins set the stage for bone marrow microenvironment-induced chemoprotection in hematologic malignancies.; Blood advances; (2023).

  • Bone Marrow Microenvironment-Induced Chemoprotection in <i>KMT2A</i> Rearranged Pediatric AML Is Overcome by Azacitidine–Panobinostat Combination; Cancers; (2023).

  • Modeling Down Syndrome Myeloid Leukemia by Sequential Introduction of <i>GATA1</i> and <i>STAG2</i> Mutations in Induced Pluripotent Stem Cells with Trisomy 21; Cells; (2022).

  • Imetelstat Induces Leukemia Stem Cell Death in Pediatric Acute Myeloid Leukemia Patient-Derived Xenografts; Journal of Clinical Medicine; (2022).

  • Mesothelin: An Immunotherapeutic Target beyond Solid Tumors; Cancers; (2022).

  • Efficacy of Flotetuzumab in Combination with Cytarabine in Patient-Derived Xenograft Models of Pediatric Acute Myeloid Leukemia; Journal of Clinical Medicine; (2022).

  • Immunotherapeutic Targeting of Mesothelin Positive Pediatric AML Using Bispecific T Cell Engaging Antibodies; Cancers; (2021).

  • Harnessing the Power of Induced Pluripotent Stem Cells and Gene Editing Technology: Therapeutic Implications in Hematological Malignancies; Cells; (2021).

  • The Menin-MLL1 interaction is a molecular dependency in NUP98-rearranged AML; Blood; (2021).

  • A 3-D hydrogel based system for hematopoietic differentiation and its use in modeling down syndrome associated transient myeloproliferative disorder; Biomaterials Science; (2021).

  • Mesothelin is a novel cell surface disease marker and potential therapeutic target in Acute Myellid Leukemia; Blood advances; (2021).

  • Modeling Transient Abnormal Myelopoiesis Using Induced Pluripotent Stem Cells and CRISPR/Cas9 Technology.; Molecular therapy. Methods & clinical development; (2020).

  • Understanding the Mechanisms by Which Epigenetic Modifiers Avert Therapy Resistance in Cancer.; Frontiers in oncology; (2020).

  • Error-corrected sequencing strategies enable comprehensive detection of leukemic mutations relevant for diagnosis and minimal residual disease monitoring.; BMC medical genomics; (2020).

  • Strong concordance between RNA structural and single nucleotide variants identified via next generation sequencing techniques in primary pediatric leukemia and patient-derived xenograft samples.; Genomics & informatics; (2020).

  • The extracellular matrix: A key player in the pathogenesis of hematologic malignancies.; Blood reviews; (2020).

  • CD81 knockout promotes chemosensitivity and disrupts in vivo homing and engraftment in acute lymphoblastic leukemia.; Blood advances; (2020).

  • Epigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia.; Leukemia research; (2017).

  • CRISPR/Cas9-Directed Reassignment of the GATA1 Initiation Codon in K562 Cells to Recapitulate AML in Down Syndrome.; Molecular therapy. Nucleic acids; (2017).

  • Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells.; The Journal of biological chemistry; (2017).

  • Eviction from the sanctuary: Development of targeted therapy against cell adhesion molecules in acute lymphoblastic leukemia.; Seminars in oncology; (2017).

  • Epigenetic drug combination overcomes osteoblast-induced chemoprotection in pediatric acute lymphoid leukemia.; Leukemia research; (2017).

  • Generation of Pediatric Leukemia Xenograft Models in NSG-B2m Mice: Comparison with NOD/SCID Mice.; Frontiers in oncology; (2016).

  • Ion dependence of Na-K-ATPase-mediated epithelial cell adhesion and migration.; American journal of physiology. Cell physiology; (2015).

  • Sodium-calcium exchanger 1 regulates epithelial cell migration via calcium-dependent extracellular signal-regulated kinase signaling.; The Journal of biological chemistry; (2015).

  • Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy.; PloS one; (2015).

  • Metformin suppresses pediatric acute myeloid leukemia cell viability and clonogenicity.; Cancer & metabolism; (2014).

  • Ellagic acid stimulates glucose transport in adipocytes and muscles through AMPK mediated pathway; Journal of diabetes and metabolism; (2012).

  • Elucidation of the glucose transport pathway in glucose transporter 4 via steered molecular dynamics simulations.; PloS one; (2011).

  • A Comprehensive Curated Reaction Map of Leptin Signaling Pathway; Jornal of Proteomics and bioinformatics; (2011).

  • Association analysis of common variants in FOXO3 with type 2 diabetes in a South Indian Dravidian population.; Gene; (2011).

  • Vanillin induces adipocyte differentiation in 3T3-L1 cells by activating extracellular signal regulated kinase 42/44.; Life sciences; (2011).

  • A case-control analysis of common variants in GIP with type 2 diabetes and related biochemical parameters in a South Indian population.; BMC medical genetics; (2010).

  • Molecular dynamics simulation studies of GLUT4: substrate-free and substrate-induced dynamics and ATP-mediated glucose transport inhibition.; PloS one; (2010).

  • Case-control analysis of SNPs in GLUT4, RBP4 and STRA6: association of SNPs in STRA6 with type 2 diabetes in a South Indian population.; PloS one; (2010).

  • Kaempferitrin inhibits GLUT4 translocation and glucose uptake in 3T3-L1 adipocytes.; Biochemical and biophysical research communications; (2009).

  • Homology modeling of GLUT4, an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors.; Journal of biomolecular structure & dynamics; (2009).

  • Gallic acid induces GLUT4 translocation and glucose uptake activity in 3T3-L1 cells.; FEBS letters; (2009).

  • Preferential association of prostate cancer cells expressing prostate specific membrane antigen to bone marrow matrix.; International journal of oncology; (2007).

  • Association of prostate-specific membrane antigen with caveolin-1 and its caveolae-dependent internalization in microvascular endothelial cells: implications for targeting to tumor vasculature.; Microvascular research; (2006).

  • Functional characterization of AAA family FtsH protease of Mycobacterium tuberculosis.; FEMS microbiology letters; (2006).

  • N-glycosylation and microtubule integrity are involved in apical targeting of prostate-specific membrane antigen: implications for immunotherapy.; Molecular cancer therapeutics; (2005).

  • Is prostate-specific membrane antigen a multifunctional protein?; American journal of physiology. Cell physiology; (2005).

  • Novel role for Na,K-ATPase in phosphatidylinositol 3-kinase signaling and suppression of cell motility.; Molecular biology of the cell; (2004).

  • Genomic organization and in vivo characterization of proteolytic activity of FtsH of Mycobacterium smegmatis SN2.; Microbiology (Reading, England); (2004).

  • A novel cytoplasmic tail MXXXL motif mediates the internalization of prostate-specific membrane antigen.; Molecular biology of the cell; (2003).

  • Prostate-specific membrane antigen association with filamin A modulates its internalization and NAALADase activity.; Cancer research; (2003).

  • Bacterial cell division protein FtsZ is a specific substrate for the AAA family protease FtsH.; Microbiology (Reading, England); (2001).

  • Cloning and expression of the gene coding for FtsH protease from Mycobacterium tuberculosis H37Rv.; Gene; (1998).

  • Newly synthesised mRNA as a probe for identification of wound responsive genes from potatoes.; Indian journal of biochemistry & biophysics; (1995).